The manufacturing sector is changing and a new manufacturing model is emerging. Recent scholarly debate has unpacked this ‘production organisation revolution’. It is therefore timely to understand what form this new manufacturing model will take in both Europe and the United States how it can contribute to regional economic development. Indeed, the core of this ‘New Manufacturing Regions’ network is to examine whether – and under what conditions – the new manufacturing model may offer the potential to develop and anchor manufacturing activities in relatively high-cost regional economies in the EU and US.